Description

Cilomilast CAS NO 164414-71-5 is a selective phosphodiesterase 4 (PDE4) inhibitor, representing a significant class of compounds in pharmaceutical research and development. Its primary value lies in its potent anti-inflammatory activity, making it a critical intermediate for the synthesis of advanced active pharmaceutical ingredients (APIs). This compound is essential for pharmaceutical manufacturers and research institutions focused on developing novel therapeutics for respiratory and inflammatory diseases.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced PDE4 inhibitor-based Active Pharmaceutical Ingredients (APIs).
• Respiratory Disease Research: Used in preclinical and clinical research for developing treatments for chronic obstructive pulmonary disease (COPD) and asthma.
• Inflammatory Condition Studies: Serves as a reference standard and research tool for investigating pathways involved in various inflammatory disorders.
• Process Development & Scale-up: Employed in chemical process R&D for optimizing synthetic routes and scaling up production of target molecules.
• Analytical Reference Standard: Used in quality control laboratories for method development, validation, and assay calibration via HPLC or LC-MS.
• Academic & Institutional Research: A vital compound for biochemical and pharmacological studies in academic settings exploring PDE4 enzyme inhibition.

Basic Information

Product Name	Cilomilast
CAS No.	164414-71-5
Molecular Formula	C20H25NO4
Molecular Weight	343.42 g/mol
Synonyms	Ariflo; SB 207499; 4-Cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexanecarboxylic Acid; cis-4-Cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylic Acid; PDE4 Inhibitor SB-207499; Cyclohexanecarboxylic acid, 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-
EINECS	Contact for details

Quality Control

Our Cilomilast is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product is suitable for use in research and development applications, with specifications typically meeting or exceeding industry standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.