Description

1,2,4-Tri-o-Butyryl-Myo-Inositol 3,5,6-Trisphosphate-Hexakis(Acetoxymethyl) Ester is a high-purity, cell-permeable derivative of inositol trisphosphate (IP3), designed for advanced biochemical and pharmacological research. This compound serves as a critical tool for studying intracellular calcium signaling pathways, enabling the controlled release of IP3 within live cells. It is essential for researchers and developers in pharmaceutical discovery, neurobiology, and cell signaling studies who require reliable, high-quality probes to investigate complex physiological processes.

Application

• Intracellular Calcium Signaling Research: Used as a cell-permeable precursor to deliver inositol 1,4,5-trisphosphate (IP3) into live cells for studying calcium mobilization and second messenger pathways.
• Pharmacological Assay Development: Serves as a key reagent in high-throughput screening (HTS) assays to identify modulators of IP3 receptor activity and calcium-dependent processes.
• Neurobiology and Cell Physiology Studies: Applied in research on neuronal communication, muscle contraction, and other cellular functions regulated by intracellular calcium release.
• Biochemical Tool Compound: Utilized in controlled experiments to elucidate the role of specific phosphoinositide derivatives in cell growth, metabolism, and apoptosis.
• Academic and Industrial R&D: A fundamental research chemical for universities, contract research organizations (CROs), and biotech companies engaged in signal transduction research.

Basic Information

Product Name	1,2,4-Tri-o-Butyryl-Myo-Inositol 3,5,6-Trisphosphate-Hexakis(Acetoxymethyl) Ester
CAS No.	164007-69-6
Molecular Formula	C41H61O27P3
Molecular Weight	1030.83 g/mol
Synonyms	IP3 Hexakis(acetoxymethyl) Ester, Butyryl Derivative; D-myo-Inositol 1,4,5-Trisphosphate, Pentaacetoxymethyl Ester; 1,2,4-Tri-O-butyryl-myo-inositol 3,5,6-trisphosphohexakis(acetoxymethyl) ester; Cell-permeable IP3 analogue; IP3/AM; Inositol 1,4,5-trisphosphate acetoxymethyl ester; caged IP3 precursor; myo-Inositol trisphosphate hexa-AM ester
EINECS	Contact for details

Quality Control

This high-purity biochemical is manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stability. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store desiccated under an inert atmosphere. Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.