Description

Propyphenazone-D3 (2-n-Methyl-D3) is a stable isotope-labeled analog of the analgesic and antipyretic agent propyphenazone, specifically deuterated at the N-methyl position. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring analytical accuracy and reliability. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical service providers for applications in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of propyphenazone and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used in tracing metabolic pathways, identifying metabolites, and conducting absorption, distribution, metabolism, and excretion (ADME) research.
• Bioanalytical Method Development & Validation: Serves as a reference compound to establish and validate robust, sensitive, and specific analytical methods in compliance with GLP/GCP guidelines.
• Clinical Pharmacology & Toxicology: Enables accurate measurement of drug concentrations in patient samples during clinical trials and therapeutic drug monitoring.
• Pharmaceutical Quality Control: Can be utilized in impurity profiling and stability-indicating assay methods for propyphenazone-containing formulations.
• Forensic & Anti-Doping Analysis: Supports the detection and confirmation of propyphenazone in forensic toxicology and sports doping control programs.

Basic Information

Product Name	Propyphenazone-D3 (2-n-Methyl-D3)
CAS No.	162935-29-7
Molecular Formula	C₁₄H₁₅D₃N₂O
Molecular Weight	233.32 g/mol
Synonyms	1,5-Dimethyl-2-(phenyl-d0)-3-(methyl-d3)-1H-pyrazol-4(5H)-one; 4-Isopropyl-2,3-dimethyl-1-phenyl-3-(methyl-d3)-pyrazol-5-one; Deuterated Propyphenazone; [2H3]-Propyphenazone; Propyphenazone (N-methyl-d3); 1-Phenyl-2,3-dimethyl-4-isopropyl-5-pyrazolone-d3; Isopropylphenazone-D3; Isopropylantipyrine-D3
EINECS	Contact for details

Quality Control

Every batch of our Propyphenazone-D3 is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (by HPLC), isotopic purity (by MS), and other critical parameters to meet the stringent requirements of analytical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0% (by NMR)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.