Description

(2S,3S,5S)-5-(tert-Butoxycarbonylamino)-2-(n-5-Thiazolylmethoxycarbonyl)Amino-1,6-Diphenyl-3-Hydroxyhexane is a sophisticated chiral building block and advanced pharmaceutical intermediate of significant commercial interest. Its precise stereochemistry and functional groups make it a critical component in the synthesis of complex, biologically active molecules, particularly in the development of protease inhibitors. This high-purity compound is essential for research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, where structural integrity and enantiomeric purity are paramount for efficacy and regulatory approval.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral and other therapeutic classes.
• Protease Inhibitor Research: Serves as a core structural unit in the research and development of novel protease inhibitor candidates.
• Peptidomimetics Development: Used in constructing complex peptidomimetic scaffolds that mimic natural peptides for enhanced stability and bioavailability.
• Asymmetric Synthesis: Employed in advanced organic synthesis to introduce specific chiral centers into target molecules with high stereoselectivity.
• Medicinal Chemistry & Drug Discovery: A valuable tool for medicinal chemists in structure-activity relationship (SAR) studies and lead optimization processes.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	(2S,3S,5S)-5-(tert-Butoxycarbonylamino)-2-(n-5-Thiazolylmethoxycarbonyl)Amino-1,6-Diphenyl-3-Hydroxyhexane
CAS No.	162849-95-8
Molecular Formula	C28H37N3O6S
Molecular Weight	543.68 g/mol
Synonyms	Boc-Amino-Thiazolyl-Carbonyl-Diphenyl-Hexanediol Derivative; (2S,3S,5S)-5-[(tert-Butoxycarbonyl)amino]-2-[[(5-thiazolylmethoxy)carbonyl]amino]-1,6-diphenyl-3-hydroxyhexane; 1,6-Diphenyl-3-hydroxy-5-(N-Boc-amino)-2-(5-thiazolylmethoxycarbonylamino)hexane; ATCH Intermediate; A Thiazole-containing Chiral Intermediate; A potential intermediate for protease inhibitors.
EINECS	Contact for details

Quality Control

Our (2S,3S,5S)-5-(tert-Butoxycarbonylamino)-2-(n-5-Thiazolylmethoxycarbonyl)Amino-1,6-Diphenyl-3-Hydroxyhexane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation by spectroscopic methods, to ensure it meets the high-purity standards required for pharmaceutical R&D and cGMP applications. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and chiral integrity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.