Description

2-Pyrrolidinone, 1-Acetyl-4-Mercapto-, (S)- (9Ci) is a high-purity, chiral heterocyclic compound featuring both acetyl and mercapto functional groups. This specialized intermediate is critical for the synthesis of complex molecules where stereochemistry and specific functional group reactivity are paramount. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in drug discovery, process chemistry, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel APIs (Active Pharmaceutical Ingredients), particularly in neurological and metabolic disorder research.
• Agrochemical Synthesis: Used in the development of advanced, stereospecific pesticides and herbicides.
• Ligand and Catalyst Precursor: Serves as a precursor for chiral ligands used in asymmetric catalysis.
• Peptidomimetic Research: Employed in the design and synthesis of peptidomimetics and protease inhibitors due to its pyrrolidinone scaffold.
• Material Science: Investigated as a monomer or modifier for specialty polymers with unique properties.
• Bioconjugation Chemistry: The mercapto group allows for use in site-specific bioconjugation strategies for antibody-drug conjugates (ADCs) or diagnostic agents.

Basic Information

Product Name	2-Pyrrolidinone, 1-Acetyl-4-Mercapto-, (S)- (9Ci)
CAS No.	162753-53-9
Molecular Formula	C6H9NO2S
Molecular Weight	159.21 g/mol
Synonyms	(S)-1-Acetyl-4-mercapto-2-pyrrolidinone; (4S)-1-Acetyl-4-sulfanyl-2-pyrrolidinone; 1-Acetyl-4-mercapto-(S)-2-pyrrolidinone; 4-Mercapto-1-acetyl-2-pyrrolidinone, (S)-; 2-Pyrrolidinone, 1-acetyl-4-mercapto-, (S)-; (S)-4-Mercapto-1-acetyl-2-pyrrolidinone
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidinone, 1-Acetyl-4-Mercapto-, (S)- (9Ci) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is easily oxidized and light-sensitive; allow it to reach ambient temperature in the sealed container before opening to minimize moisture ingress and oxidation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.