Description

3-Bromothiophene-2-Boronic Acid is a versatile organoboron building block, specifically a thiophene derivative functionalized with both bromine and a boronic acid group. This bifunctional structure makes it a critical intermediate in modern synthetic chemistry, particularly for cross-coupling reactions like the Suzuki-Miyaura reaction. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require precise molecular construction for developing active ingredients and advanced organic electronic materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, especially in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, leveraging the thiophene scaffold for biological activity.
• Material Science & OLED Development: Serves as a precursor for constructing conjugated polymers and organic semiconductors used in light-emitting diodes (OLEDs) and electronic devices.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic acid functionality enables efficient carbon-carbon bond formation with aryl/vinyl halides, crucial for creating complex biaryl and heterobiaryl structures.
• Ligand & Catalyst Preparation: Utilized in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: A valuable reagent for academic and industrial R&D in organic synthesis and methodology development.

Basic Information

Product Name	3-Bromothiophene-2-Boronic Acid
CAS No.	162607-26-3
Molecular Formula	C4H4BBrO2S
Molecular Weight	206.85 g/mol
Synonyms	(3-Bromo-2-thienyl)boronic acid; 3-Bromo-2-thiopheneboronic acid; 3-Bromothiophene-2-boronic acid pinacol ester (common derivative); 2-Borono-3-bromothiophene; B-(3-Bromo-2-thienyl)boronic acid; 3-Bromo-2-thienylboronic acid; 3-Bromothiophene-2-ylboronic acid
EINECS	Contact for details

Quality Control

Our 3-Bromothiophene-2-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We are committed to meeting the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.