Description

Megestrol-D3 is a deuterated analog of the synthetic progestin megestrol acetate, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and bioequivalence studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control units requiring precise and stable isotope-labeled reference materials.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable isotope-labeled internal standard for the quantification of megestrol acetate in biological matrices (plasma, serum, tissue) using liquid chromatography-tandem mass spectrometry.
• Pharmaceutical Research & Development: Used in method development and validation for drug metabolism and pharmacokinetics (DMPK) studies of progestational agents.
• Bioanalytical Assays: Enables high-precision measurement of megestrol acetate concentrations in clinical trials for cancer therapy (e.g., breast, endometrial) and appetite stimulation.
• Quality Control & Assurance: Serves as a critical reference material in pharmaceutical QC labs to monitor the purity and stability of megestrol acetate drug substances and products.
• Forensic and Doping Control Analysis: Potential use in confirmatory testing for the presence of synthetic progestins in forensic toxicology and anti-doping programs.
• Metabolite Identification Studies: Aids in the identification and quantification of megestrol acetate metabolites in complex biological samples.

Basic Information

Product Name	Megestrol-D3
CAS No.	162462-71-7
Molecular Formula	C24H29D3O4
Molecular Weight	387.52 g/mol (approx.)
Synonyms	Megestrol-d3; 17α-Acetoxy-6-methylpregna-4,6-diene-3,20-dione-d3; 6-Methyl-6-deuterio-17α-(acetyloxy)-6-methylpregna-4,6-diene-3,20-dione; Deuterated Megestrol Acetate; [2H3]-Megestrol Acetate; Megestrol Acetate-d3; Stable Isotope Labeled Megestrol Acetate
EINECS	Contact for details

Quality Control

Our Megestrol-D3 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.