Description

Medroxyprogesterone-D3 CAS NO 162462-69-3 is a stable isotope-labeled analog of medroxyprogesterone acetate, specifically deuterated for use as an internal standard in analytical chemistry. This high-purity reference material is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in regulated environments. It is an essential tool for pharmaceutical research, clinical laboratories, and forensic toxicology requiring precise measurement of medroxyprogesterone and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary use as a deuterated internal standard in Liquid Chromatography-Tandem Mass Spectrometry for the quantitative analysis of medroxyprogesterone acetate in biological matrices.
• Pharmaceutical R&D: Supports method development and validation for pharmacokinetic, bioavailability, and bioequivalence studies of progestin-based therapeutics.
• Clinical Diagnostics: Enables accurate measurement of drug levels in patient serum or plasma for therapeutic drug monitoring.
• Forensic and Doping Control: Used in confirmatory testing for the presence of synthetic progestins in anti-doping and forensic toxicology laboratories.
• Metabolite Studies: Facilitates the identification and quantification of medroxyprogesterone metabolites in research on drug metabolism and disposition.
• Quality Control Reference: Serves as a certified reference material for calibrating analytical instruments and verifying assay performance in QC laboratories.

Basic Information

Item	Detail
Product Name	Medroxyprogesterone-D3
CAS No.	162462-69-3
Molecular Formula	C24H31D3O4
Molecular Weight	389.55 g/mol (approx.)
Synonyms	6α-Methyl-17α-hydroxyprogesterone-16,16,17-d3 acetate; 17α-Acetoxy-6α-methylpregn-4-ene-3,20-dione-16,16,17-d3; Medroxyprogesterone Acetate-d3; MPA-d3; Deuterated Medroxyprogesterone Acetate; 6α-Methyl-17α-hydroxypregna-4-ene-3,20-dione 17-acetate-d3; 6α-Methyl-17α-(acetyloxy)pregn-4-ene-3,20-dione-16,16,17-d3
EINECS	Contact for details

Quality Control

Every batch of Medroxyprogesterone-D3 is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support its use in regulated methods, including chemical purity, isotopic purity (enrichment), and chromatographic purity as determined by advanced techniques like NMR and HPLC-MS. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Enrichment)	≥ 99.0 atom % D
Chemical Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.