Description

Talampanel CAS NO 161832-65-1 is a potent and selective non-competitive antagonist of the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) subtype of glutamate receptors. This compound is of significant interest in neuroscience research and pharmaceutical development due to its neuroprotective properties and potential therapeutic applications. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neurological disorders, stroke, epilepsy, and neurodegenerative diseases.

Application

• Neuroscience Research: A key tool compound for studying the role of AMPA receptors in synaptic transmission, plasticity, and excitotoxicity.
• Pharmaceutical R&D: Investigated as a potential therapeutic agent for conditions involving glutamate excitotoxicity, such as stroke, traumatic brain injury, and amyotrophic lateral sclerosis (ALS).
• Epilepsy Research: Used in preclinical studies to evaluate anti-convulsant and anti-epileptogenic effects due to its mechanism of action.
• Neurodegenerative Disease Models: Applied in research models of Parkinson's disease, Alzheimer's disease, and multiple sclerosis to assess neuroprotective efficacy.
• Biochemical Assays: Serves as a reference standard in high-throughput screening and receptor binding assays to discover new neuromodulators.
• Academic Research: Employed in university laboratories for fundamental studies on glutamate receptor function and neuronal signaling pathways.

Basic Information

Item	Details
Product Name	Talampanel
CAS No.	161832-65-1
Molecular Formula	C15H12N2O3
Molecular Weight	268.27 g/mol
Synonyms	7-Acetyl-5-(4-aminophenyl)-8(R)-methyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine; GYKI 53405; LY 300164; Talampanel Hydrochloride (salt form); AMPA receptor antagonist; Non-competitive AMPA antagonist
EINECS	Contact for details

Quality Control

Our Talampanel is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for critical research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research chemicals, and specifications can be aligned with client requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.