Description

5’-o-Dmtr-3’-Deoxyuridine 2’-Ced Phosphoramidite is a high-purity, specialty phosphoramidite monomer essential for the solid-phase synthesis of oligonucleotides. This compound is critical for researchers and manufacturers requiring precise control over nucleic acid sequence composition, particularly for incorporating modified nucleosides. It is primarily used by biotechnology and pharmaceutical companies engaged in the development of therapeutic oligonucleotides, diagnostic probes, and advanced research tools.

Application

• Oligonucleotide Synthesis: Key building block for the automated solid-phase synthesis of DNA and RNA strands.
• Therapeutic Oligonucleotide Development: Used in the manufacture of antisense oligonucleotides, siRNA, and aptamers for pharmaceutical applications.
• Diagnostic Probe Fabrication: Essential for creating labeled probes used in PCR, microarrays, and fluorescence in situ hybridization (FISH).
• Research & Development: Enables the study of nucleic acid structure, function, and interactions by allowing site-specific modifications.
• Synthesis of Modified Nucleosides: Facilitates the introduction of specific functional groups or labels into oligonucleotide sequences.

Basic Information

Product Name	5’-o-Dmtr-3’-Deoxyuridine 2’-Ced Phosphoramidite
CAS No.	161503-98-6
Molecular Formula	C41H51N4O9P
Molecular Weight	774.85 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-3'-deoxyuridine 2'-CED phosphoramidite; 3'-Deoxyuridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 2'-(2-cyanoethyl N,N-diisopropylphosphoramidite); DMT-3'-deoxyU-CE Phosphoramidite; 2'-Deoxy-5-O-(4,4'-dimethoxytrityl)uridine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); 3'-dU Phosphoramidite
EINECS	Contact for details

Quality Control

Our 5’-o-Dmtr-3’-Deoxyuridine 2’-Ced Phosphoramidite is manufactured under strict quality control protocols to ensure consistency and reliability for critical synthesis applications. Each batch is analyzed using advanced techniques including HPLC, 1H/31P NMR, and mass spectrometry to verify identity, purity, and suitability for oligonucleotide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.