Description

Heptakis-(6-Mercapto-6-Deoxy)-β-Cyclodextrin is a thiol-functionalized derivative of β-cyclodextrin, engineered to introduce reactive sulfhydryl groups onto the primary hydroxyl rim of the macrocyclic oligosaccharide. This modification is critical for creating stable covalent bonds with metal surfaces, polymers, and biomolecules, enabling advanced material design and surface functionalization. It is an essential building block for researchers and manufacturers in pharmaceutical development, nanotechnology, and sensor fabrication who require precise molecular conjugation and controlled assembly.

Application

• Gold Nanoparticle (AuNP) Stabilization and Functionalization: Acts as a capping and cross-linking agent to create stable, monodisperse nanoparticle suspensions for diagnostics and catalysis.
• Biosensor and Electrode Modification: Used to form self-assembled monolayers (SAMs) on gold and other metal surfaces to create highly specific and sensitive detection platforms.
• Drug Delivery System Fabrication: Serves as a key component in constructing redox-responsive or targeted delivery carriers by forming disulfide bridges.
• Polymer and Hydrogel Cross-Linking: Provides thiol groups for Michael addition or disulfide formation to create tunable, responsive polymer networks and biomaterials.
• Chiral Stationary Phases for Chromatography: Utilized to modify silica or other supports for the enantiomeric separation of pharmaceutical compounds.
• Heavy Metal Ion Capture and Sensing: Leverages the strong affinity of thiol groups for soft metal ions like mercury, lead, and cadmium for environmental remediation and detection.
• Protein and Enzyme Immobilization: Enables site-specific conjugation of biomolecules onto surfaces or within matrices while potentially preserving activity.
• Surface-Enhanced Raman Scattering (SERS) Substrates: Used to create reproducible and enhanced SERS-active surfaces for trace analysis.

Basic Information

Item	Details
Product Name	Heptakis-(6-Mercapto-6-Deoxy)-β-Cyclodextrin
CAS No.	160661-60-9
Molecular Formula	C42H70O28S7
Molecular Weight	~ 1,383.8 g/mol
Synonyms	Heptakis(6-deoxy-6-mercapto)-β-cyclodextrin; 6-Mercapto-β-cyclodextrin (heptakis derivative); β-Cyclodextrin, heptakis(6-mercapto-6-deoxy)-; Per-6-thio-β-cyclodextrin; 6-SH-β-CD; Heptakis(6-sulfanyl-6-deoxy)-β-cyclodextrin; Thiolated β-cyclodextrin; 6-Thio-β-cyclodextrin
EINECS	Contact for details

Quality Control

Our Heptakis-(6-Mercapto-6-Deoxy)-β-Cyclodextrin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and titration for thiol content determination. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C. This product is easily oxidized; prolonged exposure to air will lead to disulfide formation. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Thiol Content)	≥ 7.0 mmol/g
Water Content (KF)	≤ 5.0 %
Residue on Ignition	≤ 0.5 %
Solubility	Soluble in DMSO, DMF; partially soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.