Description

2-(T-Butyl Dimethylsilyl)-1-Methyl Imadazole is a specialized organosilicon-protected imidazole derivative, serving as a crucial building block and protecting group reagent in advanced organic synthesis. Its primary value lies in its ability to act as a versatile synthetic intermediate, particularly for the selective protection of sensitive functional groups under mild conditions. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries, where it facilitates the synthesis of complex molecules with high precision and yield.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing imidazole or other nitrogen heterocycles.
• Protecting Group Reagent: Used for the temporary protection of hydroxyl (-OH) and amine (-NH) groups during multi-step synthetic sequences, particularly where acid-labile protecting groups are required.
• Agrochemical Synthesis: Intermediate in the production of advanced fungicides, herbicides, and plant growth regulators.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, dyes, and functional materials.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and catalysis research.
• Peptide Chemistry: Can be utilized in solid-phase peptide synthesis (SPPS) for side-chain protection strategies.

Basic Information

Product Name	2-(T-Butyl Dimethylsilyl)-1-Methyl Imadazole
CAS No.	160425-48-9
Molecular Formula	C10H20N2Si
Molecular Weight	196.37 g/mol
Synonyms	1-Methyl-2-[(tert-butyldimethylsilyl)]imidazole; 2-(tert-Butyldimethylsilyl)-1-methyl-1H-imidazole; 1-Methyl-2-(tert-butyldimethylsilyl)imidazole; TBDMS-1-Methylimidazole; 2-(TBDMS)-1-Methylimidazole; N-Methyl-2-(tert-butyldimethylsilyl)imidazole; 1H-Imidazole, 1-methyl-2-[(1,1-dimethylethyl)dimethylsilyl]-
EINECS	Contact for details

Quality Control

Our 2-(T-Butyl Dimethylsilyl)-1-Methyl Imadazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.