Description

1,2,3,4-Tetrahydro-Isoquinoline-7-Carboxylic Acid is a high-purity, versatile heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its fused bicyclic structure, which serves as a critical scaffold for constructing complex molecules with targeted biological activity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of central nervous system (CNS) active compounds, potential enzyme inhibitors, and receptor modulators.
• Agrochemical Research: Used as a building block for developing new herbicides, fungicides, and plant growth regulators with novel modes of action.
• Fine Chemical Synthesis: Employed in the production of complex dyes, pigments, and specialty materials requiring a rigid, nitrogen-containing heterocycle.
• Academic & Contract Research: Serves as a valuable starting material for medicinal chemistry programs and structure-activity relationship (SAR) studies in university and CRO laboratories.
• Peptidomimetics Development: The carboxylic acid functionality allows for incorporation into peptide backbones to create novel peptidomimetic compounds with enhanced stability and bioavailability.

Basic Information

Product Name	1,2,3,4-Tetrahydro-Isoquinoline-7-Carboxylic Acid
CAS No.	160346-57-6
Molecular Formula	C10H11NO2
Molecular Weight	177.20 g/mol
Synonyms	7-Carboxy-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-7-isoquinolinecarboxylic Acid; THIQ-7-COOH; 1,2,3,4-Tetrahydroisoquinoline-7-carboxylic acid; 7-(Carboxy)-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-7-isoquinoline carboxylic acid; 7-Carboxy-1,2,3,4-tetrahydro-isoquinoline
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydro-Isoquinoline-7-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to rigorous analytical testing, including HPLC for assay and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.