Description

Fmoc-4-Diethylphosphomethyl-L-Phenylalanine is a specialized, non-natural amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is critical for introducing a phosphonate-containing side chain into peptide sequences, enabling the study of phosphorylation events and the development of enzyme inhibitors. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and medicinal chemistry who require high-purity, protected amino acids for advanced peptide production.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a key monomer for the automated synthesis of custom peptides containing phosphonated phenylalanine analogs.
• Phosphopeptide Mimetic Development: Used to create stable, non-hydrolyzable phosphonate analogs of phosphotyrosine, crucial for studying signal transduction pathways and developing therapeutic agents.
• Enzyme Inhibitor Design: Serves as a core component in the synthesis of inhibitors for phosphatases, kinases, and other phosphoryl-transfer enzymes.
• Medicinal Chemistry & Drug Discovery: Employed in the research and development of novel bioactive peptides and small molecule drugs targeting protein-protein interactions.
• Bioconjugation and Probe Synthesis: Facilitates the creation of labeled peptides for diagnostic assays, imaging studies, and biochemical probes.

Basic Information

Product Name	Fmoc-4-Diethylphosphomethyl-L-Phenylalanine
CAS No.	160253-13-4
Molecular Formula	C₂₉H₃₂NO₆P
Molecular Weight	521.54 g/mol
Synonyms	Fmoc-Phe(4-CH₂PO(OEt)₂)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(diethoxyphosphoryl)methyl]-L-phenylalanine; Fmoc-L-Phe(4-CH₂PO₃Et₂)-OH; Fmoc-4-(Diethoxyphosphorylmethyl)-L-phenylalanine; Fmoc-Phe(PO₃Et₂)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-[4-[(diethoxyphosphoryl)methyl]phenyl]propanoic acid; Fmoc-Phosphonomethylphenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-4-Diethylphosphomethyl-L-Phenylalanine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with customer requirements for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0%
Optical Rotation	-10.0° to -15.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.