Description

n-(2-Cyanoethyl-D3)-L-Valine is a deuterated amino acid derivative, specifically a labeled analog of L-valine. This compound is of critical importance for research and development in pharmaceutical and analytical chemistry, where isotopic labeling is required for precise metabolic and pharmacokinetic studies. It is primarily needed by scientists and manufacturers in the fields of deuterated pharmaceutical intermediates, internal standards for mass spectrometry, and advanced organic synthesis.

Application

• Deuterated Pharmaceutical Intermediate: Used in the synthesis of deuterated drug candidates to study metabolic stability and improve pharmacokinetic profiles.
• Internal Standard for LC-MS/MS: Serves as a critical, isotopically labeled internal standard for the accurate quantification of L-valine and related compounds in complex biological matrices.
• Metabolic Pathway Tracing: Employed in biomedical research to trace and elucidate specific metabolic pathways using deuterium as a stable isotopic tracer.
• Proteomics and Biomarker Research: Facilitates relative and absolute quantification in proteomic studies, enhancing the reliability of protein and peptide analysis.
• Synthesis of Specialty Amino Acids: Acts as a key building block for the preparation of more complex, labeled peptides and amino acid analogs.
• NMR Spectroscopy Studies: Useful in nuclear magnetic resonance (NMR) spectroscopy due to the distinct signal provided by the deuterium atoms.

Basic Information

Product Name	n-(2-Cyanoethyl-D3)-L-Valine
CAS No.	160210-22-0
Molecular Formula	C8H11D3N2O2
Molecular Weight	173.22 g/mol
Synonyms	L-Valine, N-(2-cyanoethyl-d3)-; (2S)-2-Amino-3-methylbutanoic acid 2-(cyano-d3)ethylamide; Deuterated N-2-Cyanoethyl-L-valine; d3-N-Cyanoethyl-L-valine; 2-Cyanoethyl-d3-L-valine; Valine-d3 cyanoethyl derivative; Amino acid deuterated internal standard; [D3]CN-CH2-CH2-NH-Val-OH
EINECS	Contact for details

Quality Control

Our n-(2-Cyanoethyl-D3)-L-Valine is produced under controlled conditions to ensure high isotopic and chemical purity, meeting the stringent requirements of analytical and synthetic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity by HPLC, and chiral purity. We adhere to cGMP principles for the manufacture of advanced pharmaceutical intermediates, ensuring traceability and consistency for critical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.