Description

1-Triethylsilyl-4-(Triethylsilyloxy)-1-Butyne is a specialized organosilicon compound featuring dual triethylsilyl protecting groups. This chemical serves as a versatile protected alkyne building block, crucial for advanced organic synthesis where selective deprotection strategies are required. It is primarily used by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug candidates, particularly those requiring alkyne functionality in multi-step sequences.
• Agrochemical Synthesis: Used in the development of novel active ingredients where the protected alkyne moiety is incorporated into final product structures.
• Material Science Research: Serves as a precursor in the development of silicon-containing polymers, dendrimers, and other functional materials.
• Cross-Coupling Reactions: An effective substrate in Sonogashira and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and total synthesis projects.

Basic Information

Product Name	1-Triethylsilyl-4-(Triethylsilyloxy)-1-Butyne
CAS No.	160194-28-5
Molecular Formula	C16H34OSi2
Molecular Weight	298.62 g/mol
Synonyms	1-Butyne, 4-(triethylsilyloxy)-1-(triethylsilyl)-; 4-(Triethylsilyloxy)-1-(triethylsilyl)-1-butyne; 1,4-Bis(triethylsilyl)but-1-yn-4-ol (protected form); TES-protected 4-hydroxy-1-butyne; Bis(triethylsilyl) derivative of 4-hydroxy-1-butyne; 1-TES-4-(TESO)-1-butyne
EINECS	Contact for details

Quality Control

Our 1-Triethylsilyl-4-(Triethylsilyloxy)-1-Butyne is manufactured under strict quality protocols. Each batch undergoes comprehensive analytical testing including NMR (¹H, ¹³C), GC/HPLC for purity, and identity confirmation by FT-IR to ensure it meets exacting R&D and production standards. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.