Description

D-7-Hydroxy-6,8-Diiodo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-purity, iodinated tetrahydroisoquinoline derivative serving as a critical pharmaceutical intermediate and research chemical. This compound is valued for its unique molecular structure, which is essential for synthesizing complex bioactive molecules and exploring novel therapeutic pathways. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic research institutions focused on medicinal chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new analogs with optimized biological activity.
• Biochemical Tool Compound: Employed in vitro and in vivo to study enzyme inhibition, receptor binding, and other pharmacological mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic Research: Facilitates the exploration of new synthetic methodologies and the discovery of novel chemical entities in university laboratories.
• Preclinical Development: Supports the early-stage development of new chemical entities (NCEs) requiring iodinated isoquinoline scaffolds.

Basic Information

Product Name	D-7-Hydroxy-6,8-Diiodo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	160080-87-5
Molecular Formula	C₁₀H₇I₂NO₃
Molecular Weight	458.98 g/mol
Synonyms	(3R)-7-Hydroxy-6,8-diiodo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; D-7-Hydroxy-6,8-diiodo-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; (R)-7-Hydroxy-6,8-diiodo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 6,8-Diiodo-7-hydroxy-D-tetrahydroisoquinoline-3-carboxylic acid; D-THIQ-6,8-I2-7-OH-3-COOH; 160080-87-5; D-form of the iodinated THIQ derivative
EINECS	Contact for details

Quality Control

Our D-7-Hydroxy-6,8-Diiodo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.