Description

Ethyl 1-[4-(4-Chlorophenyl)-1,3-Thiazol-2-Yl]-5-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure incorporating pyrazole, thiazole, and trifluoromethyl functional groups. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), offering a key building block for medicinal chemistry research and development. It is primarily utilized by research institutions and pharmaceutical manufacturers focused on developing new therapeutic agents, particularly in areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-inflammatory pathways, and antimicrobial agents.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the thiazole and pyrazole motifs contribute to biological activity.
• Medicinal Chemistry & Lead Optimization: Provides a versatile scaffold for structure-activity relationship (SAR) studies, enabling the exploration of new chemical space for drug discovery programs.
• Contract Research & Development (CRO/CDMO): Supplied to outsourcing partners engaged in custom synthesis and process development for client-specific molecules.
• Academic Research: Employed in university and institutional labs for fundamental studies on heterocyclic chemistry and the development of new synthetic methodologies.

Basic Information

Product Name	Ethyl 1-[4-(4-Chlorophenyl)-1,3-Thiazol-2-Yl]-5-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate
CAS No.	159885-63-9
Molecular Formula	C16H11ClF3N3O2S
Molecular Weight	401.79 g/mol
Synonyms	Ethyl 1-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate; 1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ethyl ester; 159885-63-9; Pyrazole-thiazole carboxylate intermediate; 4-(4-Chlorophenyl)-2-[4-(ethoxycarbonyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]thiazole
EINECS	Contact for details

Quality Control

Our Ethyl 1-[4-(4-Chlorophenyl)-1,3-Thiazol-2-Yl]-5-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production specifications. Our commitment to cGMP standards guarantees consistency and reliability for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.