Description

[3S-(3S,4As,8As,2’R,3’R)]-2-[3’-Amino-2’-Hydroxy-4’-(Phenyl)Thio]Butyldecahydroisoquinoline-3-n-T-Butylcarboxamide CAS NO 159878-05-4 is a sophisticated chiral organic compound featuring a complex decahydroisoquinoline scaffold with multiple stereogenic centers. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents targeting complex biological pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of advanced small-molecule drugs, where precise stereochemistry and high chemical purity are non-negotiable requirements for successful outcomes.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of potential active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) or antiviral drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with therapeutic potential.
• Asymmetric Synthesis: Serves as a valuable precursor or template in catalytic asymmetric reactions due to its defined stereochemistry.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in pharmaceutical manufacturing.
• Biochemical Probe Development: Potential use in creating tool compounds for investigating specific enzyme or receptor interactions in biological systems.

Basic Information

Item	Details
Product Name	[3S-(3S,4As,8As,2’R,3’R)]-2-[3’-Amino-2’-Hydroxy-4’-(Phenyl)Thio]Butyldecahydroisoquinoline-3-n-T-Butylcarboxamide
CAS No.	159878-05-4
Molecular Formula	C24H39N3O2S
Molecular Weight	433.65 g/mol
Synonyms	(3S,4aS,8aS)-2-[(2R,3R)-3-Amino-2-hydroxy-4-(phenylthio)butyl]decahydroisoquinoline-3-carboxamide, N-tert-Butyl; (3S,4aS,8aS)-2-[(2R,3R)-3-Amino-2-hydroxy-4-(phenylthio)butyl]decahydro-3-isoquinolinecarboxamide, N-(1,1-dimethylethyl)-; 159878-05-4; tert-Butyl (3S,4aS,8aS)-2-[(2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyl]decahydroisoquinoline-3-carboxylate (related ester); A complex thioether-containing decahydroisoquinoline derivative.
EINECS	Contact for details

Quality Control

Our [3S-(3S,4As,8As,2’R,3’R)]-2-[3’-Amino-2’-Hydroxy-4’-(Phenyl)Thio]Butyldecahydroisoquinoline-3-n-T-Butylcarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccant packs or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.