Description

[3S-(3S,4As,8As,2’R,3’R)]-2-[3’-n-Cbz-Amino-2’-Hydroxy-4’-(Phenyl)Thio]Butyldecahydroisoquinoline-3-n-T-Butylcarboxamide is a sophisticated chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex, biologically active molecules, particularly in the development of protease inhibitors and other therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of high-value Active Pharmaceutical Ingredients (APIs). The precise stereochemistry and functional groups make it an invaluable tool for constructing molecules with specific three-dimensional architectures.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and development of novel protease inhibitor drugs.
• Medicinal Chemistry Research: Used as a building block for constructing complex molecular libraries in drug discovery programs.
• Process Chemistry & Scale-up: Serves as a critical intermediate in the optimization and commercial-scale synthesis of target APIs.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce specific chiral centers into complex organic molecules.
• Peptidomimetic Development: Integral for creating non-peptide compounds that mimic the structure and function of peptides.
• Contract Manufacturing (CMO/CDMO): Supplied to contract organizations for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	[3S-(3S,4As,8As,2’R,3’R)]-2-[3’-n-Cbz-Amino-2’-Hydroxy-4’-(Phenyl)Thio]Butyldecahydroisoquinoline-3-n-T-Butylcarboxamide
CAS No.	159878-04-3
Molecular Formula	C31H41N3O4S
Molecular Weight	551.74 g/mol
Synonyms	(3S,4aS,8aS)-2-[(2R,3R)-3-[[(Benzyloxy)carbonyl]amino]-2-hydroxy-4-(phenylthio)butyl]-N-(tert-butyl)decahydroisoquinoline-3-carboxamide; Decahydroisoquinoline-3-carboxamide, 2-[3-[[(benzyloxy)carbonyl]amino]-2-hydroxy-4-(phenylthio)butyl]-N-(1,1-dimethylethyl)-, (3S,4aS,8aS)-; Cbz-Protected Amino Alcohol Isoquinoline Derivative; Advanced Chiral Building Block 159878-04-3; Pharmaceutical Intermediate CAS 159878-04-3
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and manufacturing applications. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom synthesis to meet specific purity or specification requirements is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.