Description

1-(tert-Butyldimethylsilyl)-1H-Indole-3-Boronic Acid CAS NO 159590-02-0 is a high-value, protected indole boronic acid derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling precise, palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura reaction, to construct complex heterocyclic scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key synthon for constructing indole-based active pharmaceutical ingredients (APIs) and drug candidates via Suzuki cross-coupling.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that incorporate complex indole motifs.
• Material Science Research: Serves as a precursor for creating organic electronic materials, ligands for catalysis, and functional polymers.
• Medicinal Chemistry & Drug Discovery: Enables rapid library synthesis and structure-activity relationship (SAR) studies for lead optimization.
• Academic & Contract Research: A valuable reagent for methodology development and complex molecule synthesis in academic and industrial R&D laboratories.
• Peptide Mimetics & Bioconjugation: Facilitates the introduction of indole-boronic acid functionality into peptides and biomolecules for probing biological interactions.

Basic Information

Product Name	1-(tert-Butyldimethylsilyl)-1H-Indole-3-Boronic Acid
CAS No.	159590-02-0
Molecular Formula	C₁₄H₂₂BNO₂Si
Molecular Weight	275.23 g/mol
Synonyms	1-(tert-Butyldimethylsilyl)-1H-indole-3-boronic acid; 1H-Indole-3-boronic acid, 1-[(1,1-dimethylethyl)dimethylsilyl]-; 1-TBDMS-indole-3-boronic acid; 1-(tert-Butyl(dimethyl)silyl)-1H-indole-3-boronic acid; 3-Borono-1-(tert-butyldimethylsilyl)indole; 1-Tert-butyldimethylsilylindole-3-boronic acid; N-TBDMS-indole-3-boronic acid; 1-(Tert-butyldimethylsilyl)indole-3-boronic acid
EINECS	Contact for details

Quality Control

Our 1-(tert-Butyldimethylsilyl)-1H-Indole-3-Boronic Acid is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive cross-coupling reactions. All materials undergo rigorous analytical testing, including HPLC, NMR (¹H and ¹³C), and mass spectrometry for identity and purity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥95.0% (Anhydrous basis)
Purity (HPLC, Area %)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.