Description

Ketoprofen-D3 is a deuterium-labeled analog of the non-steroidal anti-inflammatory drug (NSAID) ketoprofen, specifically designed for use as an internal standard in analytical chemistry. This high-purity stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and pharmacokinetic (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for LC-MS/MS: Critical for precise quantification of ketoprofen in complex biological matrices such as plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used as a tracer to investigate the pharmacokinetic profile, bioavailability, and metabolic pathways of ketoprofen.
• Bioanalytical Method Development and Validation: Serves as a reference standard to establish selective, sensitive, and robust analytical methods compliant with FDA and ICH guidelines.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Enables accurate measurement of drug concentrations in patient samples during clinical trials.
• Pharmaceutical Quality Control: Supports impurity profiling and assay development for ketoprofen-based drug products.
• Forensic and Toxicology Analysis: Aids in the definitive identification and quantification of ketoprofen in forensic investigations.

Basic Information

Product Name	Ketoprofen-D3
CAS No.	159490-55-8
Molecular Formula	C16H11D3FO3
Molecular Weight	258.28 g/mol
Synonyms	Ketoprofen (phenyl-D3); 2-(3-Benzoylphenyl)propionic Acid-d3; (±)-2-(3-Benzoylphenyl)propionic-3,4,5-d3 Acid; Dexketoprofen-d3; (RS)-Ketoprofen-d3; Orudis-d3; Oruvail-d3; Profenid-d3
EINECS	Contact for details

Quality Control

Our Ketoprofen-D3 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results from advanced analytical techniques including HPLC, NMR, and mass spectrometry. We adhere to relevant industry standards for stable isotope-labeled compounds, ensuring reliable performance as an internal standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.