Description

Methyl (3S,6S,8Ar)-6-[(tert-Butoxycarbonyl)Amino]-5-Oxooctahydroindolizine-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex, stereochemically defined indolizine core structure. This compound is critical for the synthesis of complex bioactive molecules, offering researchers and manufacturers a reliable building block with precise chirality. It is primarily utilized by pharmaceutical R&D teams and fine chemical producers engaged in the development of new therapeutic agents, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial chiral building block for the development of novel active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Used in the research and synthesis of potential protease inhibitors due to its constrained bicyclic amino acid-like structure.
• Peptidomimetic Chemistry: Integral for creating peptidomimetics and conformationally restricted peptides to enhance metabolic stability and bioavailability.
• Medicinal Chemistry & Drug Discovery: Provides a versatile scaffold for generating compound libraries in high-throughput screening and lead optimization programs.
• Asymmetric Synthesis: Employed in stereoselective synthesis routes to introduce complex chiral centers into target molecules.
• Contract Manufacturing & Development (CDMO): Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	Methyl (3S,6S,8Ar)-6-[(tert-Butoxycarbonyl)Amino]-5-Oxooctahydroindolizine-3-Carboxylate
CAS No.	159405-37-5
Molecular Formula	C15H24N2O5
Molecular Weight	312.36 g/mol
Synonyms	(3S,6S,8aR)-6-[(tert-Butoxycarbonyl)amino]-5-oxooctahydroindolizine-3-carboxylic acid methyl ester; Methyl (3S,6S,8aR)-6-(Boc-amino)-5-oxo-1,2,3,6,7,8-hexahydroindolizine-3-carboxylate; Boc-Protected Indolizidine Derivative; (3S,6S,8aR)-Methyl 6-((tert-butoxycarbonyl)amino)-5-oxooctahydroindolizine-3-carboxylate; 5-Oxo-6-(Boc-amino)octahydroindolizine-3-carboxylic Acid Methyl Ester; Stereoisomer of Indolizidine Intermediate; CAS 159405-37-5
EINECS	Contact for details

Quality Control

Our Methyl (3S,6S,8Ar)-6-[(tert-Butoxycarbonyl)Amino]-5-Oxooctahydroindolizine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial methods for identity and assay. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with every shipment to ensure compliance with your research or cGMP manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Keep container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.