Description

Chloroacetyl-D2 Chloride is a deuterated derivative of chloroacetyl chloride, where two hydrogen atoms are replaced by deuterium. This isotopic labeling makes it a critical reagent for the synthesis of stable isotope-labeled compounds, particularly in pharmaceutical research and development. It is essential for scientists and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, labeled intermediates for metabolic studies, tracer analysis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for creating deuterium-labeled active pharmaceutical ingredients (APIs) for drug discovery and development.
• Metabolic Pathway Tracers: Used in the preparation of isotopically labeled probes to study drug metabolism and pharmacokinetics (DMPK) via mass spectrometry.
• Agrochemical Research: Synthesis of labeled pesticide and herbicide analogs for environmental fate and residue analysis studies.
• NMR Spectroscopy Standards: Serves as a precursor for compounds used as internal standards or shift reagents in nuclear magnetic resonance (NMR) spectroscopy.
• Organic Synthesis & Material Science: Employed in specialized organic reactions where the deuterium label is incorporated into polymers or advanced organic materials.
• Proteomics & Biomarker Research: Facilitates the synthesis of heavy-isotope labeled peptides and other biomolecules for quantitative proteomics.

Basic Information

Product Name	Chloroacetyl-D2 Chloride
CAS No.	159301-43-6
Molecular Formula	C2D2Cl2O
Molecular Weight	116.95 g/mol
Synonyms	Deuterochloroacetyl Chloride; Chloroacetyl-d2 Chloride; (Dichloroacetyl-d2) Chloride; 2,2-Dideutero-2-chloroacetyl Chloride; Acetyl-d2 Chloride, 2-chloro-; Chloro(d2)acetyl Chloride; [D2]-Chloroacetyl Chloride; Monochloroacetic-d2 Acid Chloride
EINECS	Contact for details

Quality Control

Our Chloroacetyl-D2 Chloride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, GC, and GC-MS, to confirm isotopic purity (D-content typically >98 atom % D) and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Keep away from heat, sparks, open flames, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Purity (NMR)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.