Description

L-Anti-Endo-3,4-Methanopyrrolidinedicarboxylic Acid CAS NO 159262-32-5 is a high-purity, stereochemically defined bicyclic pyrrolidine derivative. This compound serves as a critical chiral building block and a potent, selective antagonist for glutamate receptors, particularly targeting the NMDA subtype. It is essential for researchers and manufacturers in advanced pharmaceutical development, specifically for creating neuroprotective agents and investigating neurological pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel central nervous system (CNS) active drugs.
• Neurological Research: Used as a selective NMDA receptor antagonist in preclinical studies for stroke, epilepsy, and neurodegenerative diseases.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new neuroprotective compounds.
• Biochemical Research: Acts as a tool compound for studying glutamatergic neurotransmission and receptor pharmacology.
• Process Development: Serves as a reference standard and starting material for scaling up GMP-grade active pharmaceutical ingredients (APIs).

Basic Information

Product Name	L-Anti-Endo-3,4-Methanopyrrolidinedicarboxylic Acid
CAS No.	159262-32-5
Molecular Formula	C9H11NO4
Molecular Weight	197.19 g/mol
Synonyms	(3S,3aS,6aR)-Hexahydro-2-oxo-1H-cyclopenta[b]pyrrole-3,5-dicarboxylic Acid; L-anti-Endo-3,4-Methanopyrrolidine-3,5-dicarboxylic Acid; LY 235959 Precursor; NMDA Receptor Antagonist LY 235959 Intermediate; (3S,3aS,6aR)-1,2,3,3a,4,6a-Hexahydrocyclopenta[b]pyrrole-3,5-dicarboxylic Acid 2-Oxide; NSC 694554
EINECS	Contact for details

Quality Control

Our L-Anti-Endo-3,4-Methanopyrrolidinedicarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.