Description

(R)-Ethyl 3-Amino-2,5-Dioxopyrrolidine-3-Carboxylate is a high-purity chiral building block and synthetic intermediate of significant value in advanced organic synthesis. This compound is essential for the development of novel pharmaceuticals and bioactive molecules due to its stereochemically defined pyrrolidine-2,5-dione (succinimide) core. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex, optically active target structures.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic disorders.
• Protease Inhibitor Research: Core scaffold for developing inhibitors of enzymes like DPP-4, relevant for diabetes treatment research.
• Agrochemical Synthesis: Building block for creating novel, enantiomerically pure herbicides and fungicides with improved efficacy and environmental profiles.
• Asymmetric Catalysis Ligand Precursor: Used in the preparation of chiral ligands and organocatalysts for stereoselective transformations.
• Peptidomimetics & Conformational Studies: Serves as a constrained amino acid analog for designing peptide mimics and studying protein folding.
• Material Science Research: Intermediate for synthesizing specialty polymers and functional materials with specific chiral properties.

Basic Information

Product Name	(R)-Ethyl 3-Amino-2,5-Dioxopyrrolidine-3-Carboxylate
CAS No.	159213-18-0
Molecular Formula	C7H10N2O4
Molecular Weight	186.17 g/mol
Synonyms	(R)-Ethyl 3-Aminosuccinimidate; (3R)-3-Amino-2,5-dioxo-1-pyrrolidinecarboxylic Acid Ethyl Ester; Ethyl (3R)-3-Amino-2,5-dioxopyrrolidine-3-carboxylate; (R)-3-Amino-2,5-dioxo-pyrrolidine-3-carboxylic Acid Ethyl Ester; (R)-Ethyl 3-Amino-2,5-dioxo-1-pyrrolidinecarboxylate; (R)-Ethyl 3-Aminosuccinimide-3-carboxylate; (R)-3-(Ethoxycarbonyl)-3-aminosuccinimide
EINECS	Contact for details

Quality Control

Our (R)-Ethyl 3-Amino-2,5-Dioxopyrrolidine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.