Description

Docosahexaenoic Acid-D5 Ethyl Ester is a deuterium-labeled analog of the essential ω-3 fatty acid DHA, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is critical for ensuring the accuracy and reliability of quantitative analyses in complex biological matrices. It is primarily utilized by research institutions, pharmaceutical companies, and analytical laboratories engaged in lipidomics, metabolic studies, and pharmacokinetic research.

Application

• Internal Standard for Mass Spectrometry (MS): Essential for the precise quantification of endogenous DHA and its metabolites in LC-MS/MS and GC-MS applications.
• Biomedical and Nutritional Research: Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) of ω-3 fatty acids.
• Pharmaceutical Development: Supports bioanalytical method development and validation for DHA-containing drug formulations and nutraceuticals.
• Clinical Diagnostics: Enables accurate measurement of DHA levels in plasma, serum, and tissue samples for nutritional status assessment.
• Food and Supplement Analysis: Employed in the quality control and potency verification of ω-3 fortified foods and dietary supplements.
• Lipidomics: A key tool in comprehensive lipid profiling studies to understand lipid metabolism and related disease mechanisms.

Basic Information

Product Name	Docosahexaenoic Acid-D5 Ethyl Ester
CAS No.	159146-01-7
Molecular Formula	C24H31D5O2
Molecular Weight	~365.56 g/mol
Synonyms	(all-Z)-4,7,10,13,16,19-Docosahexaenoic-21,21,22,22,22-d5 Acid Ethyl Ester; Ethyl (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoate-d5; DHA-d5 Ethyl Ester; Deuterated DHA Ethyl Ester; 22:6n-3-d5 Ethyl Ester; Ethyl Docosahexaenoate-d5; 21,21,22,22,22-Pentadeuteroethyl all-cis-docosa-4,7,10,13,16,19-hexaenoate
EINECS	Contact for details

Quality Control

Our Docosahexaenoic Acid-D5 Ethyl Ester is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, GC-MS, and HPLC, to confirm structure, deuterium incorporation, and purity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and solvent residues is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). This product is easily oxidized and moisture-sensitive; allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98% (chemical purity)
Isotopic Enrichment	≥ 98 atom % D
Isotopic Purity (MS)	≥ 95% D5
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.