Description

tert-Butyl 6-Hydroxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a protected heterocyclic amine derivative, serving as a crucial synthetic intermediate in advanced organic chemistry. Its primary value lies in providing a versatile and stable scaffold for constructing complex pharmaceutical molecules, particularly those targeting central nervous system and cardiovascular pathways. This high-purity building block is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of tetrahydroisoquinoline-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in the discovery and development of novel drug candidates, particularly for neurological and cardiovascular targets.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and herbicides.
• Fine Chemical Manufacturing: Serves as a precursor for dyes, pigments, and other specialty chemicals requiring the isoquinoline core structure.
• Academic & Contract Research: Valuable reagent for methodological development and complex molecule synthesis in academic and CRO laboratories.

Basic Information

Product Name	tert-Butyl 6-Hydroxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	158984-83-9
Molecular Formula	C14H19NO3
Molecular Weight	249.31 g/mol
Synonyms	2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-6-hydroxy-, 1,1-dimethylethyl ester; 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; Boc-6-OH-Tic-OH; 6-Hydroxy-Tic-OtBu; 158984-83-9; tert-Butyl 6-hydroxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Hydroxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to prevent exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.