Description

Methyl 5-Chloro-3-Chlorosuphonylthiophene-2-Carboxylate is a high-purity, multi-functional chemical intermediate of significant importance in advanced organic synthesis. Its core value lies in its dual reactive sites, the chlorosulfonyl and ester groups, which allow for versatile derivatization to create complex molecular architectures. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it serves as a critical building block for active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the thiophene scaffold for enhanced bioactivity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers and conductive materials with unique electronic properties.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing high-performance, light-fast organic dyes and pigments.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for fine chemical companies offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	Methyl 5-Chloro-3-Chlorosuphonylthiophene-2-Carboxylate
CAS No.	158439-31-7
Molecular Formula	C7H5Cl2NO4S2
Molecular Weight	294.15 g/mol
Synonyms	Methyl 5-chloro-3-(chlorosulfonyl)thiophene-2-carboxylate; 5-Chloro-3-chlorosulfonyl-2-thiophenecarboxylic acid methyl ester; 2-Thiophenecarboxylic acid, 5-chloro-3-(chlorosulfonyl)-, methyl ester; Methyl 5-chloro-3-(chlorosulfonyl)thiophene-2-carboxylate; 3-Chlorosulfonyl-5-chlorothiophene-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 5-Chloro-3-Chlorosuphonylthiophene-2-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability. All material is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to verify identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications. We operate under a quality system aligned with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.