Description

1-[4-(2-Chloroethoxy)Phenyl]-2-(Ethyl-D5)-2-Phenylethanone is a deuterated derivative of a key pharmaceutical intermediate, where five hydrogen atoms in the ethyl group are replaced with deuterium. This strategic isotopic labeling is crucial for enhancing metabolic stability and enabling advanced pharmacokinetic and metabolic studies in drug discovery and development. It is an essential building block for researchers and manufacturers in the pharmaceutical industry, particularly those developing and analyzing new active pharmaceutical ingredients (APIs).

Application

• Deuterated Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of deuterium-labeled drug candidates, leveraging the kinetic isotope effect for improved metabolic profiles.
• Metabolic Studies & Drug Discovery: Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) for the accurate quantification and metabolic pathway analysis of its non-deuterated counterpart.
• API Development: Employed in the research and process development of new Active Pharmaceutical Ingredients (APIs) requiring isotopic labeling for patent life-cycle management or enhanced efficacy.
• Biochemical Research: Utilized in mechanistic studies to trace biochemical pathways and understand drug-receptor interactions at a molecular level.
• Reference Standard: Acts as a high-purity certified reference material for quality control and regulatory compliance in pharmaceutical manufacturing.

Basic Information

Product Name	1-[4-(2-Chloroethoxy)Phenyl]-2-(Ethyl-D5)-2-Phenylethanone
CAS No.	157738-48-2
Molecular Formula	C18H14D5ClO2
Molecular Weight	311.84 g/mol
Synonyms	2-(Ethyl-d5)-1-[4-(2-chloroethoxy)phenyl]-2-phenylethanone; 1-[4-(2-Chloroethoxy)phenyl]-2-(1,1,2,2,2-pentadeuteroethyl)-2-phenylethanone; Deuterated Chloroethoxy Phenylethanone; (Ethyl-d5)-Chloroethoxy Benzyl Ketone; α-(4-(2-Chloroethoxy)benzyl)-β,β,β-trideuteriophenethyl-d2 ketone; Pentadeuteroethyl Analog of Chloroethoxy Phenylethanone
EINECS	Contact for details

Quality Control

Our 1-[4-(2-Chloroethoxy)Phenyl]-2-(Ethyl-D5)-2-Phenylethanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C), HPLC, and LC-MS, to confirm chemical identity, isotopic purity (D-enrichment), and chemical purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept in a desiccated environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.