Description

(R)-4-Mercapto-2-Pyrrolidone is a high-value, chiral building block and key intermediate in organic synthesis, characterized by its unique pyrrolidone ring bearing a thiol functional group. This compound matters for its role in constructing complex molecules, particularly in the development of pharmaceuticals and advanced materials where stereochemistry is critical. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications ranging from drug discovery to catalyst design.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in neurological and metabolic disorder research.
• Asymmetric Catalysis: Serves as a precursor or ligand in the development of chiral catalysts for enantioselective synthesis.
• Peptidomimetics & Bioactive Molecule Design: Used to incorporate thiol-functionalized pyrrolidone motifs into peptide analogs and other bioactive compounds.
• Agrochemical Synthesis: Intermediate in the production of advanced, stereochemically-defined crop protection agents.
• Material Science Research: Building block for functional polymers and smart materials that require specific thiol reactivity and chirality.
• Chemical Biology Probes: Utilized in the development of probes and inhibitors that target enzymes with cysteine residues in their active sites.

Basic Information

Product Name	(R)-4-Mercapto-2-Pyrrolidone
CAS No.	157429-42-0
Molecular Formula	C4H7NOS
Molecular Weight	117.17 g/mol
Synonyms	(R)-4-Mercapto-2-pyrrolidinone; (R)-4-Sulfanyl-2-pyrrolidinone; (4R)-4-Sulfanyl-2-pyrrolidinone; (R)-4-Thiol-2-pyrrolidone; (R)-4-Mercaptopyrrolidin-2-one; (R)-4-Mercapto-2-oxopyrrolidine; (R)-4-Mercapto-dihydro-2H-pyrrol-2-one; (R)-4-Mercapto-2-pyrrolidinone
EINECS	Contact for details

Quality Control

Our (R)-4-Mercapto-2-Pyrrolidone is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC), enantiomeric excess (Chiral HPLC), and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated place. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.