Description

Dl-Homocysteic-3,3,4,4-D4 Acid is a deuterated analog of homocysteic acid, a key excitatory amino acid and a potent agonist of NMDA receptors. This stable isotope-labeled compound is essential for advanced research requiring precise metabolic and pharmacokinetic tracing. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and academic institutions focused on neuroscience, biomarker discovery, and drug development.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical quantitative reference standard in mass spectrometry for the accurate measurement of homocysteic acid and related metabolites in complex biological matrices.
• Neuroscience Research: Used as a tool compound to study NMDA receptor function, excitotoxicity, and glutamatergic signaling pathways without interference from endogenous compounds.
• Metabolic Pathway Tracing: Enables detailed investigation of sulfur amino acid metabolism and transsulfuration pathways in in vitro and in vivo studies.
• Biomarker Development: Facilitates the development and validation of highly sensitive and specific clinical assays for neurological and cardiovascular disease biomarkers.
• Pharmaceutical Reference Standard: Employed in the quality control and regulatory submission packages for novel drug candidates targeting neurological disorders.
• Isotope Dilution Mass Spectrometry (IDMS): Provides the gold standard for achieving high accuracy and precision in quantitative analytical methods.

Basic Information

Product Name	Dl-Homocysteic-3,3,4,4-D4 Acid
CAS No.	157203-91-3
Molecular Formula	C4H3D4NO6S
Molecular Weight	185.17 g/mol
Synonyms	DL-Homocysteic-3,3,4,4-d4 Acid; (RS)-2-Amino-4-sulfobutanoic-3,3,4,4-d4 Acid; Homocysteic Acid-d4; 2-Amino-4-sulfobutanoic Acid-d4; Deuterated DL-Homocysteate; DL-HCA-d4; NMDA Receptor Agonist-d4; Stable Isotope Labeled Homocysteic Acid
EINECS	Contact for details

Quality Control

Every batch of Dl-Homocysteic-3,3,4,4-D4 Acid is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure high chemical purity and isotopic enrichment, critical for sensitive research applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting results from NMR, HPLC, and mass spectrometry. Our quality commitment aligns with the standards expected for pharmaceutical reference materials and advanced research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.