Description

Methyl 3-Hydroxy-5-Trifluoromethylthiophene-2-Carboxylate is a high-value, multi-functional heterocyclic building block characterized by its thiophene core, trifluoromethyl group, and ester functionality. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiophene and trifluoromethyl motifs.
• Material Science Precursor: Serves as a building block for functionalized polymers and organic electronic materials due to its conjugated thiophene system.
• Ligand and Catalyst Development: Employed in the synthesis of novel ligands for metal-catalyzed cross-coupling reactions and asymmetric synthesis.
• Fluorine Chemistry Research: An important compound for studying structure-activity relationships (SAR) in medicinal and agrochemical discovery programs.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and commercial production of client-specific molecules.

Basic Information

Product Name	Methyl 3-Hydroxy-5-Trifluoromethylthiophene-2-Carboxylate
CAS No.	157162-16-8
Molecular Formula	C7H5F3O3S
Molecular Weight	226.17 g/mol
Synonyms	Methyl 3-hydroxy-5-(trifluoromethyl)thiophene-2-carboxylate; 2-Carbomethoxy-3-hydroxy-5-trifluoromethylthiophene; 3-Hydroxy-5-(trifluoromethyl)thiophene-2-carboxylic acid methyl ester; Methyl 3-hydroxy-5-(trifluoromethyl)-2-thiophenecarboxylate; 5-(Trifluoromethyl)-3-hydroxythiophene-2-carboxylic acid methyl ester; 157162-16-8; 3-Hydroxy-5-trifluoromethyl-thiophene-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-Hydroxy-5-Trifluoromethylthiophene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.