Description

(S)-4-Benzyl-3-Propionyl-2-Oxazolidinone-D3 is a high-purity, deuterium-labeled chiral auxiliary and synthetic intermediate. This compound is critical for enabling precise stereochemical control and isotopic tracing in advanced pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of complex, optically active molecules.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Employed as a versatile Evans-type auxiliary for the stereoselective alkylation, aldol, and Michael addition reactions in the construction of complex drug candidates.
• Isotope-Labeled Intermediate: The deuterium (D3) label makes it essential for pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies, aiding in drug discovery and development.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) where high enantiomeric purity is required, particularly in central nervous system (CNS) and antiviral drug classes.
• Process Chemistry & Scale-Up: Serves as a key building block in the development of robust, scalable synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Academic & Contract Research: Utilized in university and contract research organization (CRO) settings for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(S)-4-Benzyl-3-Propionyl-2-Oxazolidinone-D3
CAS No.	156451-08-0
Molecular Formula	C₁₃H₁₂D₃NO₃
Molecular Weight	236.29 g/mol
Synonyms	(4S)-4-Benzyl-3-(1-oxopropyl)-2-oxazolidinone-d3; (S)-4-Benzyl-3-propionyl-2-oxazolidinone-d3; (S)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone-d3; Evans Auxiliary-d3; (S)-N-Propionyl-4-benzyl-2-oxazolidinone-d3; Deuterated (S)-4-Benzyl-3-propionyloxazolidin-2-one; (S)-Benzyl Propionyl Oxazolidinone-d3; N-Propionyl-(4S)-(-)-4-benzyl-2-oxazolidinone-d3
EINECS	Contact for details

Quality Control

Our (S)-4-Benzyl-3-Propionyl-2-Oxazolidinone-D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, NMR, and mass spectrometry, to ensure high chemical and isotopic purity, enantiomeric excess (ee), and conformity to specifications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.