Description

3-(4-Nitrophenyl)Bicyclo[1.1.1]Pentane-1-Carboxylicacid is a high-value, synthetically challenging bicyclic building block featuring a strained [1.1.1]propellane core. This compound matters as a key intermediate for advanced materials science and pharmaceutical research, enabling the synthesis of novel, three-dimensional molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries for creating innovative active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, leveraging its unique three-dimensional structure to improve binding affinity and metabolic stability.
• Agrochemical Research: Used in the development of next-generation herbicides and pesticides, where the bicyclo[1.1.1]pentane moiety acts as a bioisostere for aromatic rings or tert-butyl groups to optimize physicochemical properties.
• Materials Science & Polymer Chemistry: Incorporated as a rigid, high-strain monomer or cross-linking agent to create polymers and advanced materials with tailored mechanical, thermal, or optical properties.
• Chemical Biology & Probe Development: Employed in the design of chemical probes and molecular tools for studying biological systems, where its distinct shape aids in target specificity.
• Organic Synthesis & Methodology: Acts as a benchmark substrate for developing new synthetic methodologies, particularly ring-opening and cross-coupling reactions involving strained carbocycles.
• Ligand & Catalyst Design: Utilized to construct novel, sterically demanding ligands for asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	3-(4-Nitrophenyl)Bicyclo[1.1.1]Pentane-1-Carboxylicacid
CAS No.	156329-80-5
Molecular Formula	C12H11NO4
Molecular Weight	233.22 g/mol
Synonyms	3-(4-Nitrophenyl)bicyclo[1.1.1]pentane-1-carboxylic acid; 1-(4-Nitrophenyl)-3-carboxybicyclo[1.1.1]pentane; 4-(3-Carboxybicyclo[1.1.1]pentan-1-yl)nitrobenzene; Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(4-nitrophenyl)-; 156329-80-5; 3-(p-Nitrophenyl)bicyclo[1.1.1]pentane-1-carboxylic acid; 4-(1-Carboxybicyclo[1.1.1]pentan-3-yl)nitrobenzene
EINECS	Contact for details

Quality Control

Our 3-(4-Nitrophenyl)Bicyclo[1.1.1]Pentane-1-Carboxylicacid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality ensures material suitable for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to prevent degradation. Keep away from strong acids and organic solvents during storage and handling.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.