Description

(3-Hydroxy-3H-1,2,3-Triazolo[4,5-B]Pyridinato-O)Tri-1-Pyrrolidinylphosphonium Hexafluorophosphate is a specialized organophosphorus reagent, widely recognized as a highly effective coupling agent in peptide synthesis. Its primary value lies in its ability to facilitate amide bond formation with minimal racemization, making it critical for producing high-purity peptides. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors engaged in advanced organic synthesis and API development.

Application

• Peptide Synthesis: As a key coupling reagent for solid-phase and solution-phase peptide synthesis, enabling efficient amide bond formation.
• Pharmaceutical Intermediates: In the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs) requiring high stereochemical fidelity.
• Bioconjugation: For linking peptides, proteins, or other biomolecules to carriers, labels, or solid supports in diagnostic and therapeutic applications.
• Organic Synthesis: As a versatile reagent for constructing amides, esters, and other carboxylic acid derivatives in complex molecule assembly.
• Combinatorial Chemistry: Used in high-throughput screening libraries for drug discovery to generate diverse arrays of peptide-based compounds.
• Academic & Industrial Research: A valuable tool for synthetic chemists in universities, R&D centers, and CROs (Contract Research Organizations).

Basic Information

Product Name	(3-Hydroxy-3H-1,2,3-Triazolo[4,5-B]Pyridinato-O)Tri-1-Pyrrolidinylphosphonium Hexafluorophosphate
CAS No.	156311-83-0
Molecular Formula	C17H28F6N6OP2
Molecular Weight	548.38 g/mol
Synonyms	PyAOP; (7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium Hexafluorophosphate; 1-[(1-Cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino-morpholino]-uronium Hexafluorophosphate (common mis-association); HATU Analog; Coupling Reagent PyAOP; Tripyrrolidinophosphonium 1,1,3,3-tetramethyluronium hexafluorophosphate derivative; 3-Hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine-3-yloxy-tris(pyrrolidino)phosphonium Hexafluorophosphate
EINECS	Contact for details

Quality Control

Our (3-Hydroxy-3H-1,2,3-Triazolo[4,5-B]Pyridinato-O)Tri-1-Pyrrolidinylphosphonium Hexafluorophosphate is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive synthetic applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry verification. A detailed Certificate of Analysis (COA) is supplied with each batch, confirming compliance with our stringent in-house specifications tailored for research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent decomposition. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.