Description

1,3-Dioxino4,5,6-Hiindolizin-8-Ol, Octahydro-9-(Methoxymethoxy)-2,2-Dimethyl-, Methanesulfonate (Ester), 3As-(3A.Alpha.,8.Alpha.,9.Beta.,9A.Beta.,9B.Alpha.)- is a complex, high-purity organic intermediate with a defined stereochemistry. This compound is valued for its role as a key chiral building block in advanced synthetic pathways, particularly in pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting the central nervous system or with specific stereochemical requirements.
• Organic Synthesis Research: Used in academic and industrial laboratories for methodological development and the construction of complex heterocyclic frameworks.
• Process Chemistry: Serves as a defined starting material or intermediate in the scale-up and optimization of API manufacturing processes under GMP conditions.
• Asymmetric Catalysis Studies: Employed as a substrate or ligand precursor in the development of new catalytic asymmetric transformations.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	1,3-Dioxino4,5,6-Hiindolizin-8-Ol, Octahydro-9-(Methoxymethoxy)-2,2-Dimethyl-, Methanesulfonate (Ester), 3As-(3A.Alpha.,8.Alpha.,9.Beta.,9A.Beta.,9B.Alpha.)-
CAS No.	156205-89-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(3aα,8α,9β,9aβ,9bα)-Octahydro-9-(methoxymethoxy)-2,2-dimethyl-1,3-dioxino[4,5,6-hi]indolizin-8-ol methanesulfonate; 1,3-Dioxino[4,5,6-hi]indolizin-8-ol, octahydro-9-(methoxymethoxy)-2,2-dimethyl-, methanesulfonate (ester), (3aα,8α,9β,9aβ,9bα)-; 156205-89-9; (3aR,8R,9S,9aR,9bS)-Octahydro-9-(methoxymethoxy)-2,2-dimethyl-1,3-dioxino[4,5,6-hi]indolizin-8-yl methanesulfonate; Methanesulfonic acid (3aα,8α,9β,9aβ,9bα)-octahydro-9-(methoxymethoxy)-2,2-dimethyl-1,3-dioxino[4,5,6-hi]indolizin-8-yl ester
EINECS	Contact for details

Quality Control

This high-value intermediate is produced and controlled under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure identity, strength, and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications. Our quality commitment supports development under GMP for starting materials where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. For long-term storage, it is recommended to keep the material at 2-8°C under an inert atmosphere. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.