Description

6-Indolizinecarbonitrile, Octahydro-1,7,8-Trihydroxy-, 1S-(1.Alpha.,6.Beta.,7.Alpha.,8.Beta.,8A.Beta.)- is a complex, stereochemically defined indolizine derivative that serves as a critical chiral building block in advanced organic synthesis. Its multi-functional structure, featuring hydroxyl groups and a nitrile moiety, makes it a versatile precursor for constructing pharmacologically active molecules. This high-purity intermediate is primarily sought by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents.
• Asymmetric Synthesis: Utilized as a sophisticated starting material or intermediate in stereoselective chemical reactions.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Fine Chemical Production: Serves as a building block for the synthesis of complex, high-value specialty chemicals.
• Academic Research: Used in universities and R&D labs for methodological development in organic and heterocyclic chemistry.
• Bioconjugate Chemistry: Potential use in creating labeled compounds or probes due to its functionalizable groups.

Basic Information

Product Name	6-Indolizinecarbonitrile, Octahydro-1,7,8-Trihydroxy-, 1S-(1.Alpha.,6.Beta.,7.Alpha.,8.Beta.,8A.Beta.)-
CAS No.	156205-59-3
Molecular Formula	C11H16N2O3
Molecular Weight	224.26 g/mol
Synonyms	(1S,6R,7S,8R,8aR)-Octahydro-1,7,8-trihydroxy-6-indolizinecarbonitrile; (1S,6R,7S,8R,8aR)-1,7,8-Trihydroxyoctahydroindolizine-6-carbonitrile; 6-Cyano-1,7,8-trihydroxyoctahydroindolizine (stereoisomer); Swainsonine derivative; Indolizidine alkaloid intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced chemical intermediate adheres to strict quality management protocols, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles to meet the exacting standards of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.