Description

1,7,8-Indolizinetriol, 6-Fluorooctahydro-, Triacetate (Ester), 1S-(1.Alpha.,6.Beta.,7.Alpha.,8.Beta.,8A.Beta.)- is a high-purity, fluorinated indolizine derivative with a complex stereochemistry that makes it a valuable synthetic intermediate. This compound matters for its role in advanced pharmaceutical research, particularly in the development of novel active pharmaceutical ingredients (APIs) and complex natural product analogs. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific fluorinated and polyhydroxylated motifs into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, especially those targeting central nervous system (CNS) disorders or infectious diseases.
• Agrochemical Research: Used in the development of novel herbicides or pesticides where the fluorinated indolizine core can impart unique biological activity and metabolic stability.
• Chiral Pool Synthesis: Serves as a sophisticated chiral starting material or auxiliary for asymmetric synthesis due to its defined stereocenters at the 1, 6, 7, 8, and 8a positions.
• Medicinal Chemistry Probe: Employed in structure-activity relationship (SAR) studies to explore the impact of fluorination and hydroxyl group protection on biological potency and pharmacokinetic properties.
• Natural Product Analog Synthesis: Intermediate in the semi-synthesis or total synthesis of complex natural products containing the indolizidine or related alkaloid skeletons.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes to fluorinated target molecules under Current Good Manufacturing Practice (cGMP) conditions.

Basic Information

Product Name	1,7,8-Indolizinetriol, 6-Fluorooctahydro-, Triacetate (Ester), 1S-(1.Alpha.,6.Beta.,7.Alpha.,8.Beta.,8A.Beta.)-
CAS No.	156205-45-7
Molecular Formula	C16H23FNO6
Molecular Weight	344.36 g/mol
Synonyms	(1S,6R,7S,8R,8aR)-6-Fluoro-1,7,8-trihydroxyoctahydroindolizine-1,7,8-triyl triacetate; 6-Fluoro-1,7,8-trihydroxyoctahydroindolizine-1,7,8-triyl triacetate (1S,6R,7S,8R,8aR)-; 6-Fluoro-1,7,8-trihydroxyoctahydroindolizine triacetate; 1S-(1α,6β,7α,8β,8aβ)-6-Fluoro-1,7,8-trihydroxyoctahydroindolizine-1,7,8-triyl triacetate; Fluorinated Indolizine Triacetate; 6-Fluoroindolizinetriol Triacetate; 156205-45-7; CAS 156205-45-7
EINECS	Contact for details

Quality Control

Our 1,7,8-Indolizinetriol, 6-Fluorooctahydro-, Triacetate (Ester) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant quality management standards, and our products are suitable for use in cGMP-compliant development workflows upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light) and should be handled in accordance with good laboratory practices for handling fine chemicals.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.