Description

Thymine-Methyl-D3-6-D CAS NO 156054-85-2 is a deuterium-labeled isotopologue of thymine, a fundamental pyrimidine nucleobase. This high-purity, stable isotope-labeled compound is essential for advanced analytical and research applications where precise molecular tracking is required. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for use as an internal standard in mass spectrometry, metabolic pathway studies, and the development of labeled pharmaceutical compounds.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for the accurate analysis of nucleobases, nucleosides, and related metabolites in complex biological matrices.
• Metabolic Research & Tracing: Used in deuterium-labeling studies to investigate the metabolism, biosynthesis, and degradation pathways of thymine and related nucleic acid components.
• Pharmaceutical Development: Employed in the research and development of deuterated drug candidates, where the incorporation of deuterium can alter pharmacokinetic properties.
• Biochemical Assays: Functions as a specialized reagent in enzymatic studies and assays involving thymine metabolism, such as those related to thymidine phosphorylase.
• NMR Spectroscopy: Acts as a valuable probe in nuclear magnetic resonance spectroscopy due to the distinct signal of deuterium atoms, aiding in structural elucidation and dynamic studies.
• Quality Control & Reference Material: Provides a certified reference material for ensuring the accuracy and precision of analytical methods in quality control laboratories.

Basic Information

Item	Details
Product Name	Thymine-Methyl-D3-6-D
CAS No.	156054-85-2
Molecular Formula	C5H3D4N2O2
Molecular Weight	129.13 g/mol
Synonyms	5-Methyl-2,4-dioxo-3,4-dihydropyrimidine (methyl-d3, 6-d); [Methyl-d3,6-d]-Thymine; Thymine-d4; 5-Methyl-d3-uracil-6-d; 2,4-Dihydroxy-5-methyl-d3-pyrimidine-6-d; 5-Methyl-2,4(1H,3H)-pyrimidinedione-d4; Isotopically Labeled Thymine
EINECS	Contact for details

Quality Control

Every batch of Thymine-Methyl-D3-6-D is manufactured and analyzed under strict quality management systems to ensure exceptional isotopic and chemical purity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA), detailing isotopic enrichment (D%), chemical purity, and analytical results, is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.