Description

2-((4-Bromo-2-Fluorophenyl)Methyl)-6-Fluorospiro(Isoquinoline-4(1H),3'-Pyrrolidine)-1,2',3,5'(2H)-Tetrone is a high-purity, complex heterocyclic organic compound featuring a unique spirocyclic structure. This compound is of significant value as a key advanced intermediate in the synthesis of novel pharmaceutical agents, particularly in the development of targeted small-molecule therapies. It is primarily sought by pharmaceutical R&D organizations, contract research organizations (CROs), and fine chemical manufacturers engaged in cutting-edge drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical building block in the research and synthesis of potential drug candidates, especially for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize biological activity profiles.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study specific enzyme functions and biological pathways.
• Process Chemistry Development: Employed in scaling up synthetic routes for new chemical entities (NCEs) during pre-clinical and clinical development phases.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, non-commercial compounds for client-specific research projects.

Basic Information

Product Name	2-((4-Bromo-2-Fluorophenyl)Methyl)-6-Fluorospiro(Isoquinoline-4(1H),3'-Pyrrolidine)-1,2',3,5'(2H)-Tetrone
CAS No.	155683-53-7
Molecular Formula	C20H13BrF2N2O4
Molecular Weight	463.23 g/mol
Synonyms	6-Fluoro-2-[(4-bromo-2-fluorophenyl)methyl]spiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone; 2-[(4-Bromo-2-fluorophenyl)methyl]-6-fluorospiro[1,3-dihydroisoquinoline-4,3'-pyrrolidine]-1,2',3,5'-tetrone; 155683-53-7; Spiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone, 2-((4-bromo-2-fluorophenyl)methyl)-6-fluoro-; 6-Fluoro-2-((4-bromo-2-fluorobenzyl)spiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for advanced pharmaceutical intermediates. Every batch is characterized and controlled using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to a cGMP-compliant quality management system to ensure traceability and consistency for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.