Description

5-(Trifluoromethoxy)Benzo[D]Thiazole-2-Thiol is a high-purity, specialized heterocyclic compound featuring a benzothiazole core functionalized with a trifluoromethoxy group and a thiol moiety. This unique structure makes it a versatile and critical building block in advanced organic synthesis, particularly for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating compounds with enhanced biological activity and specific physicochemical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Used as a core scaffold for developing new-generation herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science Research: Serves as a monomer or functional additive in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Ligand and Catalyst Development: The thiol group allows for coordination to metals, making it useful for creating novel ligands in catalytic systems.
• Chemical Biology Probe: Utilized in research to modify proteins or create activity-based probes for studying enzymatic function.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring fluorinated benzothiazole derivatives.

Basic Information

Item	Detail
Product Name	5-(Trifluoromethoxy)Benzo[D]Thiazole-2-Thiol
CAS No.	155559-82-3
Molecular Formula	C8H4F3NOS2
Molecular Weight	251.25 g/mol
Synonyms	2-Mercapto-5-(trifluoromethoxy)benzothiazole; 5-(Trifluoromethoxy)-2-benzothiazolethiol; 2-Benzothiazolethiol, 5-(trifluoromethoxy)-; 5-Trifluoromethoxybenzothiazole-2-thiol; 2-Mercapto-5-trifluoromethoxybenzothiazole; 5-(Trifluoromethoxy)-1,3-benzothiazole-2-thiol; 155559-82-3; 5-Trifluoromethoxy-2-mercaptobenzothiazole
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethoxy)Benzo[D]Thiazole-2-Thiol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements of our clients. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and propensity to be easily oxidized (store under inert atmosphere), it is recommended to handle and store the material under an inert atmosphere such as nitrogen or argon for long-term stability, especially after opening the original container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.