Description

Cholesterol-3-o-Methylthiophosphonate CAS NO 155538-88-8 is a high-purity, synthetic cholesterol derivative functionalized with a methylthiophosphonate group at the 3-position. This specialized modification makes it a critical intermediate for advanced research and development in pharmaceutical chemistry, particularly in the synthesis of novel drug candidates and bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sterol-based drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation & Probe Development: Used to create labeled cholesterol analogs for studying lipid metabolism, membrane biology, and cellular signaling pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Lipidomics Standard: Acts as a reference standard or internal standard in analytical methods like LC-MS for lipid quantification and profiling.
• Material Science: Potential precursor for functionalized sterols used in advanced materials and delivery systems.

Basic Information

Product Name	Cholesterol-3-o-Methylthiophosphonate
CAS No.	155538-88-8
Molecular Formula	C28H49O3PS
Molecular Weight	496.73 g/mol
Synonyms	3-[(Methylthio)phosphinyloxy]cholest-5-ene; Cholest-5-en-3β-yl methylthiophosphonate; Cholesterol 3-Methylthiophosphonate; 3β-Hydroxycholest-5-ene 3-Methylthiophosphonate; Methylthiophosphonic Acid Cholesterol Ester; Cholesterol O-Methyl Thiophosphonate
EINECS	Contact for details

Quality Control

Every batch of Cholesterol-3-o-Methylthiophosphonate is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent batch-to-batch quality. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere if the material is hygroscopic to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.