Description

8-(3,5-Difluorophenyl)-1,4-Dioxaspiro(4,5)Decan-8-Ol is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic and difluorophenyl structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel, fluorinated active pharmaceutical ingredients (APIs) for central nervous system (CNS) and metabolic disorder treatments.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, where the difluorophenyl moiety enhances biological activity and environmental stability.
• Organic Synthesis: Serves as a versatile precursor for constructing complex spirocyclic and heterocyclic compounds in medicinal chemistry and material science research.
• Fluorine Chemistry Studies: Employed as a model compound in academic and industrial research to study the effects of fluorine substitution on chemical reactivity and physical properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialty intermediates.

Basic Information

Product Name	8-(3,5-Difluorophenyl)-1,4-Dioxaspiro(4,5)Decan-8-Ol
CAS No.	155366-01-1
Molecular Formula	C15H16F2O3
Molecular Weight	282.28 g/mol
Synonyms	8-(3,5-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol; 1,4-Dioxaspiro[4.5]decan-8-ol, 8-(3,5-difluorophenyl)-; 8-(3,5-Difluorophenyl)-8-hydroxy-1,4-dioxaspiro[4.5]decane; 155366-01-1; 8-Hydroxy-8-(3,5-difluorophenyl)-1,4-dioxaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our 8-(3,5-Difluorophenyl)-1,4-Dioxaspiro(4,5)Decan-8-Ol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be sensitive to moisture; ensure containers are sealed under an inert atmosphere if specified for your grade.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.