Description

(E)-5-Chloro-1-Penteneboronicacidpin is a high-purity organoboron building block, specifically a vinylboronic ester, essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and advanced materials research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific chlorinated alkene motifs.
• Material Science Research: Employed in the creation of organic electronic materials, liquid crystals, and functional polymers through controlled coupling reactions.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile coupling partner with various aryl and vinyl halides to introduce the 5-chloro-1-pentenyl moiety.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules and probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	(E)-5-Chloro-1-Penteneboronicacidpin
CAS No.	154820-95-8
Molecular Formula	C11H20BClO2
Molecular Weight	230.54 g/mol
Synonyms	(E)-5-Chloro-1-pentenylboronic acid pinacol ester; (E)-5-Chloropent-1-en-1-ylboronic acid pinacol ester; trans-5-Chloro-1-pentenylboronic acid pinacol ester; 5-Chloro-1-pentenylboronic Acid Pinacol Ester (E-isomer); (E)-5-Chloro-1-pentenyl-Bpin; 154820-95-8; B-[(1E)-5-Chloro-1-penten-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Every batch of (E)-5-Chloro-1-Penteneboronicacidpin undergoes rigorous analytical testing to ensure identity, purity, and lot-to-lot consistency suitable for sensitive coupling reactions. Our quality management system supports the stringent requirements of research and development. A comprehensive Certificate of Analysis (COA) detailing purity (typically by NMR and HPLC), isomeric ratio, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, well-ventilated place. Keep away from heat, sparks, and open flame. Due to its sensitivity to oxidation and moisture, containers should be sealed under inert gas after each use to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0% (Area %)
Isomeric Purity (E/Z ratio)	≥98:2 (by GC or HPLC)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.