Description

5-Fluoro-Benzo[B]Thiophene-2-Carboxylic Acid Methyl Ester is a high-purity fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters as a critical intermediate in the development of novel pharmaceuticals and agrochemicals, enabling the introduction of both sulfur-containing and fluorine-substituted aromatic systems. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates targeting various therapeutic areas, leveraging the fluorine atom for metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the benzo[b]thiophene core provides unique biological activity.
• Material Science Precursor: Serves as a monomer or precursor for the synthesis of specialty polymers and organic electronic materials.
• Chemical Synthesis Reagent: Employed in cross-coupling reactions, such as Suzuki or Stille couplings, to create complex biaryl systems for further functionalization.
• Ligand and Catalyst Development: Useful scaffold for constructing novel ligands in asymmetric catalysis and coordination chemistry.

Basic Information

Product Name	5-Fluoro-Benzo[B]Thiophene-2-Carboxylic Acid Methyl Ester
CAS No.	154630-32-7
Molecular Formula	C10H7FO2S
Molecular Weight	210.22 g/mol
Synonyms	Methyl 5-Fluorobenzo[b]thiophene-2-carboxylate; 5-Fluorobenzo[b]thiophene-2-carboxylic acid methyl ester; 2-Methoxycarbonyl-5-fluorobenzo[b]thiophene; 5-Fluoro-1-benzothiophene-2-carboxylic Acid Methyl Ester; 154630-32-7; 5-F-BT-2-COOMe; Methyl 5-fluorobenzo[b]thiophene-2-carboxylate
EINECS	Contact for details

Quality Control

Our 5-Fluoro-Benzo[B]Thiophene-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and physical data are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.