Description

3-Fluorothiophene-2-Carbonitrile is a high-value fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the fluorine atom and nitrile group impart unique electronic and steric properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce fluorothiophene motifs into complex molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides where the fluorothiophene core enhances biological activity and metabolic stability.
• Material Science Building Block: Employed in the development of advanced organic electronic materials, such as semiconductors and liquid crystals, due to its electron-withdrawing characteristics.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and library synthesis.
• Fluorine Chemistry: Acts as a model compound for studying fluorination reactions and the behavior of fluorinated heterocycles in various chemical transformations.

Basic Information

Product Name	3-Fluorothiophene-2-Carbonitrile
CAS No.	154499-46-4
Molecular Formula	C5H2FNS
Molecular Weight	127.14 g/mol
Synonyms	2-Cyano-3-fluorothiophene; 3-Fluoro-2-thiophenecarbonitrile; 3-Fluorothiophene-2-carbonitrile; 3-Fluorothiophene-2-carbonitrile (9CI); 2-Thiophenecarbonitrile, 3-fluoro-; 3-Fluoro-2-cyanothiophene; 3-Fluorothienyl-2-carbonitrile
EINECS	Contact for details

Quality Control

Our 3-Fluorothiophene-2-Carbonitrile is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing purity, identity, and impurity profiles. Our quality systems support development from research quantities to commercial scale, ensuring reliable supply for critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed and stored under an inert atmosphere if long-term storage is required.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.