Description

3H-Pyrrolizin-3-One, 7-(Hydroxymethyl)- (9Ci) is a high-purity, advanced pharmaceutical intermediate with the CAS number 154367-62-1. This compound is valued for its unique pyrrolizine core, which serves as a critical building block in the synthesis of complex bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in oncology and anti-inflammatory drug discovery.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for novel active pharmaceutical ingredients (APIs), especially those targeting specific enzymatic pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Organic Synthesis Building Block: Employed in multi-step organic syntheses to construct complex heterocyclic frameworks due to its reactive hydroxymethyl group.
• Biochemical Research: Potential use as a probe or ligand in biochemical assays to study protein-ligand interactions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	3H-Pyrrolizin-3-One, 7-(Hydroxymethyl)- (9Ci)
CAS No.	154367-62-1
Molecular Formula	C8H9NO2
Molecular Weight	151.16 g/mol
Synonyms	7-(Hydroxymethyl)-3H-pyrrolizin-3-one; 7-(Hydroxymethyl)pyrrolizin-3-one; 154367-62-1; Pyrrolizin-3-one, 7-(hydroxymethyl)-; 7-Hydroxymethyl-3H-pyrrolizin-3-one
EINECS	Contact for details

Quality Control

Our 3H-Pyrrolizin-3-One, 7-(Hydroxymethyl)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.