Description

Thiophene, 2-[(4-Fluorophenyl)Methyl]-5-Iodo- is a high-value, halogenated thiophene derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a fluorinated phenyl ring with an iodinated thiophene core, enabling precise structural modifications in target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiophene scaffold.
• Material Science: Serves as a monomer or functional unit in the creation of specialized polymers, organic semiconductors, and liquid crystals.
• Cross-Coupling Reactions: The iodine atom at the 5-position makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to construct complex biaryl systems.
• Chemical Biology: Employed as a molecular probe or tag due to the distinct reactivity and spectroscopic properties of the iodine and fluorine atoms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client R&D projects.

Basic Information

Product Name	Thiophene, 2-[(4-Fluorophenyl)Methyl]-5-Iodo-
CAS No.	154355-88-1
Molecular Formula	C11H8FIS
Molecular Weight	318.15 g/mol
Synonyms	5-Iodo-2-[(4-fluorophenyl)methyl]thiophene; 2-[(4-Fluorobenzyl)]-5-iodothiophene; 2-(4-Fluorobenzyl)-5-iodothiophene; 5-Iodo-2-(4-fluorobenzyl)thiophene; 154355-88-1; Thiophene, 2-[(4-fluorophenyl)methyl]-5-iodo-; AKOS005258065
EINECS	Contact for details

Quality Control

Every batch of Thiophene, 2-[(4-Fluorophenyl)Methyl]-5-Iodo- is produced and analyzed under strict quality management protocols. We employ advanced analytical techniques including HPLC, GC-MS, NMR, and elemental analysis to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all critical parameters are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.