Description

Atreleuton is a potent and selective inhibitor of the 5-lipoxygenase (5-LO) enzyme, which plays a key role in the biosynthesis of leukotrienes. This mechanism of action makes it a valuable pharmaceutical intermediate for research and development targeting inflammatory and respiratory conditions. It is primarily utilized by pharmaceutical manufacturers and contract research organizations (CROs) engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced anti-inflammatory drug candidates.
• Biochemical Research: Used as a reference standard and tool compound in pharmacological studies of the leukotriene pathway.
• Drug Discovery & Development: Serves as a core structure for medicinal chemistry programs aimed at developing new 5-LO inhibitors.
• Academic Research: Employed in university and institutional labs for investigating the role of leukotrienes in disease models.
• Pre-clinical Studies: Utilized in the formulation of test articles for in vitro and in vivo efficacy and safety assessments.

Basic Information

Product Name	Atreleuton
CAS No.	154355-75-6
Molecular Formula	C20H19NO4S
Molecular Weight	369.44 g/mol
Synonyms	Atreleuton; 2-[3-[3-(4-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]benzoic Acid; 2-[3-[3-(4-Fluorophenoxy)phenyl]-1-methylprop-2-en-1-yl]benzoic Acid; ABT-761; ZD-2138; 5-Lipoxygenase Inhibitor ABT-761; Benzoic acid, 2-[3-[3-(4-fluorophenoxy)phenyl]-1-methyl-2-propen-1-yl]-
EINECS	Contact for details

Quality Control

Our Atreleuton is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.